Engineering and Application of LOV2-Based Photoswitches.

  title={Engineering and Application of LOV2-Based Photoswitches.},
  author={Sheryl Zimmerman and Brian Kuhlman and Hayretin Yumerefendi},
  journal={Methods in enzymology},
Cellular optogenetic switches, a novel class of biological tools, have improved our understanding of biological phenomena that were previously intractable. While the design and engineering of these proteins has historically varied, they are all based on borrowed elements from plant and bacterial photoreceptors. In general terms, each of the optogenetic switches designed to date exploits the endogenous light-induced change in photoreceptor conformation while repurposing its effect to target a… CONTINUE READING
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