Engineering an in vitro model of a functional ligament from bone to bone.

  title={Engineering an in vitro model of a functional ligament from bone to bone.},
  author={Jennifer Z. Paxton and Liam M Grover and Keith Baar},
  journal={Tissue engineering. Part A},
  volume={16 11},
For musculoskeletal tissues that transmit loads during movement, the interfaces between tissues are essential to minimizing injury. Therefore, the reproduction of functional interfaces within engineered musculoskeletal tissues is critical to the successful transfer of the technology to the clinic. The goal of this work was to rapidly engineer ligament equivalents in vitro that contained both the soft tissue sinew and a hard tissue bone mimetic. This goal was achieved using cast brushite (CaHPO… CONTINUE READING
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