Engineering an HIV Envelope Protein to Activate Germline B Cell Receptors of Broadly Neutralizing VRC01-Class Antibodies

@inproceedings{Mcguire2013EngineeringAH,
  title={Engineering an HIV Envelope Protein to Activate Germline B Cell Receptors of Broadly Neutralizing VRC01-Class Antibodies},
  author={Amanda Mcguire and Anita M. Dreyer and Sara B. Hoot and Adriana Lippy and Archibald Stuart and Kristen W Cohen and John Jardine and Sergey Menis and Johannes F. Scheid and Andrew Phillip West and William R. Schief and Leonidas Stamatatos},
  year={2013}
}
We show an inverse relationship between HIV-specific responses (production of IL-2, IL-13, IL-21, IFN-c, CD4 polyfunctionality, i.e. production of at least two cytokines) and the peak of viral load during ATI. Those cellular immune responses were positively correlated to genes associated with T cell functional modules (M4.1, M4.15) at w16 and negatively correlated to genes associated with inflammation (e.g. EGLIN1, H2AFY, LTBR). Specifically, IL-21 secretion, that was associated with control of… CONTINUE READING