Engineering adenylate cyclases regulated by near-infrared window light.

  title={Engineering adenylate cyclases regulated by near-infrared window light.},
  author={Min-Hyung Ryu and In-Hye Kang and Mathew D Nelson and Tricia M Jensen and Anna I Lyuksyutova and Jessica Siltberg-Liberles and David M Raizen and Mark Gomelsky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 28},
Bacteriophytochromes sense light in the near-infrared window, the spectral region where absorption by mammalian tissues is minimal, and their chromophore, biliverdin IXα, is naturally present in animal cells. These properties make bacteriophytochromes particularly attractive for optogenetic applications. However, the lack of understanding of how light-induced conformational changes control output activities has hindered engineering of bacteriophytochrome-based optogenetic tools. Many… CONTINUE READING

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Near - infrared lightactivated proteins

  • M Gomelsky, MH Ryu
  • US Patent
  • 2013

Near-infrared light-activated proteins. US Patent 20,130,030,041; WO 2013016693 (pending)

  • M Gomelsky, MH Ryu
  • Publication date Jan
  • 2013
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