Engineering adeno-associated virus 2 vectors for targeted gene delivery to atherosclerotic lesions

Abstract

Targeted delivery of biological agents to atherosclerotic plaques may provide a novel treatment and/or useful tool for imaging of atherosclerosis in vivo. However, there are no known viral vectors that possess the desired tropism. Two plaque-targeting peptides, CAPGPSKSC (CAP) and CNHRYMQMC (CNH) were inserted into the capsid of adeno-associated virus 2… (More)
DOI: 10.1038/sj.gt.3303077

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