Engineering activated protein C to maximize therapeutic efficacy.


The anticoagulant-activated protein C (APC) acts not solely as a crucial regulator of thrombus formation following vascular injury, but also as a potent signalling enzyme with important functions in the control of both acute and chronic inflammatory disease. These properties have been exploited to therapeutic effect in diverse animal models of inflammatory… (More)
DOI: 10.1042/BST20140312


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