Engineering a vascularised 3D in vitro model of cancer progression

Abstract

The hallmark of tumours is the ability of cancerous cells to promote vascular growth, to disseminate and invade to distant organs. The metastatic process is heavily influenced by the extracellular matrix (ECM) density and composition of the surrounding tumour microenvironment. These microenvironmental cues, which include hypoxia, also regulate the… (More)
DOI: 10.1038/srep44045

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