Engineering a thymus

Abstract

Engineering a patient’s own T cells to express tumor-targeting heterodimeric T-cell receptors (TCRs) is a promising therapeutic strategy. Even so, development of this method has been undermined by unintended dimerization of endogenous and exogenous TCR chains, resulting in hybrid receptors that lead to off-target effects and autoimmunity, and by suboptimal… (More)
DOI: 10.1038/nbt.2225

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Cite this paper

@article{Defrancesco2012EngineeringAT, title={Engineering a thymus}, author={Laura Defrancesco}, journal={Nature Biotechnology}, year={2012}, volume={30}, pages={411-411} }