Engineering a scaffold-free 3D tumor model for in vitro drug penetration studies.

@article{Ong2010EngineeringAS,
  title={Engineering a scaffold-free 3D tumor model for in vitro drug penetration studies.},
  author={S. W. Joelle Ong and Ziqing Zhao and Talha Arooz and Deqiang Zhao and Shufang Zhang and Tiehua Du and Martin Wasser and Danny van Noort and Hanry Yu},
  journal={Biomaterials},
  year={2010},
  volume={31 6},
  pages={1180-90}
}
Three-dimensional (3D) in vitro cultures are recognized for recapitulating the physiological microenvironment and exhibiting high concordance with in vivo conditions. In cancer research, the multi-cellular tumor spheroid (MCTS) model is an established 3D cancer model that exhibits microenvironmental heterogeneity close to that of tumors in vivo. However, the established process of MCTS formation is time-consuming and often uncontrolled. Here, we report a method for engineering MCTS using a… CONTINUE READING

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