Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

@article{Martin2003EngineeringAM,
  title={Engineering a mevalonate pathway in Escherichia coli for production of terpenoids},
  author={Vincent J. J. Martin and Douglas J. Pitera and Sydnor T. Withers and Jack D. Newman and Jay D. Keasling},
  journal={Nature Biotechnology},
  year={2003},
  volume={21},
  pages={796-802}
}
Isoprenoids are the most numerous and structurally diverse family of natural products. Terpenoids, a class of isoprenoids often isolated from plants, are used as commercial flavor and fragrance compounds and antimalarial or anticancer drugs. Because plant tissue extractions typically yield low terpenoid concentrations, we sought an alternative method to produce high-value terpenoid compounds, such as the antimalarial drug artemisinin, in a microbial host. We engineered the expression of a… 

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