Engineering a Rugged Nanoscaffold To Enhance Plug-and-Display Vaccination

@article{Bruun2018EngineeringAR,
  title={Engineering a Rugged Nanoscaffold To Enhance Plug-and-Display Vaccination},
  author={Theodora U J Bruun and A. Andersson and S. Draper and M. Howarth},
  journal={ACS Nano},
  year={2018},
  volume={12},
  pages={8855 - 8866}
}
Nanoscale organization is crucial to stimulating an immune response. Using self-assembling proteins as multimerization platforms provides a safe and immunogenic system to vaccinate against otherwise weakly immunogenic antigens. Such multimerization platforms are generally based on icosahedral viruses and have led to vaccines given to millions of people. It is unclear whether synthetic protein nanoassemblies would show similar potency. Here we take the computationally designed porous… Expand
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