Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors

@article{Roybal2016EngineeringTC,
  title={Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors},
  author={Kole T. Roybal and J. Williams and Leonardo Morsut and Levi J. Rupp and Isabel Kolinko and Joseph H. Choe and Whitney J. Walker and Krista A. McNally and W. Lim},
  journal={Cell},
  year={2016},
  volume={167},
  pages={419-432.e16}
}
Redirecting T cells to attack cancer using engineered chimeric receptors provides powerful new therapeutic capabilities. However, the effectiveness of therapeutic T cells is constrained by the endogenous T cell response: certain facets of natural response programs can be toxic, whereas other responses, such as the ability to overcome tumor immunosuppression, are absent. Thus, the efficacy and safety of therapeutic cells could be improved if we could custom sculpt immune cell responses… Expand
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