• Corpus ID: 14056619

Engineering Nanoscale Biological Molecular Motors

@article{Korosec2017EngineeringNB,
  title={Engineering Nanoscale Biological Molecular Motors},
  author={Chapin S Korosec and Nancy R. Forde},
  journal={arXiv: Biological Physics},
  year={2017}
}
Understanding the operation of biological molecular motors, nanoscale machines that transduce electrochemical energy into mechanical work, is enhanced by bottom-up strategies to synthesize novel motors. 

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SHOWING 1-10 OF 20 REFERENCES
The Tumbleweed: Towards a synthetic protein motor
Biomolecular motors have inspired the design and construction of artificial nanoscale motors and machines based on nucleic acids, small molecules, and inorganic nanostructures. However, the high
Design and Construction of the Lawnmower, An Artificial Burnt-Bridges Motor
TLDR
This work proposes the concept of a protein-based, burnt-bridges ratchet, inspired by biological examples, and utilizes protease blades to cleave peptide substrates, and uses the asymmetric substrate-product interface arising from productive cleavage to bias subsequent diffusion on the track (lawn).
A Bipedal DNA Brownian Motor with Coordinated Legs
TLDR
An autonomous DNA bipedal walker is constructed that coordinates the action of its two legs by cyclically catalyzing the hybridization of metastable DNA fuel strands, which leads to a chemically ratcheted walk along a directionally polar DNA track.
The force generated by a single kinesin molecule against an elastic load.
  • E. MeyhöferJ. Howard
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1995
TLDR
The force required to stop a single kinesin molecule was 5.4 +/- 1.0 pN (mean +/- SD; n = 16), independent of the stiffness of the fiber, the damping from the fluid, and whether the ATP concentration was high or low.
Two binding partners cooperate to activate the molecular motor Kinesin-1
TLDR
It is shown that binding of JIP1 and FEZ1 to Kinesin-1 is sufficient to activate the motor for MT binding and motility, the first demonstration of the activation of a MT-based motor by cellular binding partners.
Controlled microfluidic switching in arbitrary time-sequences with low drag.
TLDR
This work uses total-internal reflection fluorescence microscopy to characterize the time-dependent change in concentration during switching of solutions near the device surface, and finds that well-defined fluid interfaces are formed in the immediate vicinity of the surface ensuring distinct switching events.
Interstitial Collagenase Is a Brownian Ratchet Driven by Proteolysis of Collagen
We show that activated collagenase (MMP-1) moves processively on the collagen fibril. The mechanism of movement is a biased diffusion with the bias component dependent on the proteolysis of its
On the hand-over-hand mechanism of kinesin.
  • Qiang ShaoY. Gao
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2006
TLDR
Good agreement is obtained between the calculated and experimental results on the external force dependence of the walking speed, the forward/backward step ratio, and dwell times for both forward and backward steps.
Internal strain drives spontaneous periodic buckling in collagen and regulates remodeling
TLDR
An internal strain relief model involving reversible structural rearrangements quantitatively reproduces the observed spatial patterning and fluctuations of defects and provides a mechanism for tension-dependent stabilization of fibrillar collagen.
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