Engineered vascular-targeting antibody-interferon-gamma fusion protein for cancer therapy.

  title={Engineered vascular-targeting antibody-interferon-gamma fusion protein for cancer therapy.},
  author={Christina Ebbinghaus and Roberto Ronca and M. Kaspar and Dragan Grabulovski and Alexander Berndt and Hartwig Kosmehl and Luciano Zardi and Dario Neri},
  journal={International journal of cancer},
  volume={116 2},
A number of cytokines are either approved drugs or are in advanced clinical trials, yet these biopharmaceuticals do not typically localize efficiently in solid tumors and manifest their therapeutic potential at the expense of severe side effects. The targeted delivery of cytokines to solid tumors is a promising avenue for increasing the therapeutic index of these biopharmaceuticals. We engineered a fusion protein between scFv(L19), a human antibody fragment specific to the EDB domain of… CONTINUE READING


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