Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity.

@article{Hoffmeister2002EngineeredUG,
  title={Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity.},
  author={D. C. Hoffmeister and Barrie Wilkinson and Graham Foster and Philip J Sidebottom and Koji Ichinose and Andreas Bechthold},
  journal={Chemistry & biology},
  year={2002},
  volume={9 3},
  pages={287-95}
}
Combinatorial biosynthesis is a promising technique used to provide modified natural products for drug development. To enzymatically bridge the gap between what is possible in aglycon biosynthesis and sugar derivatization, glycosyltransferases are the tools of choice. To overcome limitations set by their intrinsic specificities, we have genetically engineered the protein regions governing nucleotide sugar and acceptor substrate specificities of two urdamycin deoxysugar glycosyltransferases… CONTINUE READING

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