Engineered systems for detection and discovery of nuclear hormone-like compounds.

@article{Gillies2008EngineeredSF,
  title={Engineered systems for detection and discovery of nuclear hormone-like compounds.},
  author={Alison R. Gillies and Georgios Skretas and David P. Wood},
  journal={Biotechnology progress},
  year={2008},
  volume={24 1},
  pages={8-16}
}
Biomolecular engineering has many applications in the identification of potentially therapeutic compounds. An important class of these compounds is those that bind and modulate the activity of the human nuclear hormone receptors (NHRs). NHRs are typically made up of clearly defined domains with known function, including one that mediates ligand recognition and NHR activation. Engineered systems that include these ligand-binding domains (LBDs) can be used to identify potential therapeutic… CONTINUE READING