Engineered redox-responsive PEG detachment mechanism in PEGylated nano-graphene oxide for intracellular drug delivery.

@article{Wen2012EngineeredRP,
  title={Engineered redox-responsive PEG detachment mechanism in PEGylated nano-graphene oxide for intracellular drug delivery.},
  author={Huiyun Wen and Chunyan Dong and Haiqing Dong and Aijun Shen and Wenjuan Xia and Xiaojun Cai and Yanyan Song and Xuequan Li and Yongyong Li and Donglu Shi},
  journal={Small},
  year={2012},
  volume={8 5},
  pages={760-9}
}
In biomedical applications, polyethylene glycol (PEG) functionalization has been a major approach to modify nanocarriers such as nano-graphene oxide for particular biological requirements. However, incorporation of a PEG shell poses a significant diffusion barrier that adversely affects the release of the loaded drugs. This study addresses this critical issue by employing a redox-responsive PEG detachment mechanism. A PEGylated nano-graphene oxide (NGO-SS-mPEG) with redox-responsive detachable… CONTINUE READING
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PEGylated Nano-Graphene Oxide for Intracellular Drug Delivery

  • a B. Romberg, W. E. Hennink, G. Storm, Pharm. Res
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