Engineered proteinticles for targeted delivery of siRNA to cancer cells

@inproceedings{Lee2015EngineeredPF,
  title={Engineered proteinticles for targeted delivery of siRNA to cancer cells},
  author={Eun Jung Lee and Suyeong Lee and Yoon Sik Kang and Ju Hee Ryu and Koo Chul Kwon and Eunji Jo and Ji Young Yhee and Ick Chan Kwon and Kwangmeyung Kim and Jeewon Lee},
  year={2015}
}
Considering the problems of small interfering RNA (siRNA) delivery using traditional viral and nonviral vehicles, a new siRNA delivery system to enhance efficiency and safety needs to be developed. Here human ferritin-based proteinticles are genetically engineered to simultaneously display various functional peptides on the surface of proteinticles: cationic peptide to capture siRNA, tumor cell targeting and penetrating peptides, and enzymatically cleaved peptide to release siRNA inside tumor… CONTINUE READING

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