Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo

@article{Hartmann1998EngineeredMO,
  title={Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo},
  author={Guido R. Hartmann and Terence Prospero and V Brinkmann and {\"O}emil Ozcelik and Greg Winter and Jonathan Hepple and Sarah J. Batley and Friedhelm Bladt and Martin Sachs and Carmen Birchmeier and Walter Birchmeier and Ermanno Gherardi},
  journal={Current Biology},
  year={1998},
  volume={8},
  pages={125-135}
}
BACKGROUND Although a number of growth factors bind cell-surface heparan sulphate proteoglycans (HSPGs), the role of this interaction is unclear except for fibroblast growth factor which requires HSPG binding for signalling. Hepatocyte growth factor/scatter factor (HGF/SF) plays important roles in mammalian development and tissue regeneration and acts on target cells through a specific receptor tyrosine kinase encoded by the c-met proto-oncogene. This factor also binds HSPGs with high affinity… CONTINUE READING

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