Engineered human dicentric chromosomes show centromere plasticity

@article{Higgins2005EngineeredHD,
  title={Engineered human dicentric chromosomes show centromere plasticity},
  author={Anne W. Higgins and Karen M. Gustashaw and Huntington F. Willard},
  journal={Chromosome Research},
  year={2005},
  volume={13},
  pages={745-762}
}
The centromere is essential for the faithful distribution of a cell's genetic material to subsequent generations. Despite intense scrutiny, the precise genetic and epigenetic basis for centromere function is still unknown. Here, we have used engineered dicentric human chromosomes to investigate mammalian centromere structure and function. We describe three classes of dicentric chromosomes isolated in different cell lines: functionally monocentric chromosomes, in which one of the two genetically… CONTINUE READING

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