Engineered gene over-expression as a method of drug target identification.

Abstract

The proposed target of aminobisphosphonate (aBP) bone resorption inhibitors, both in mammalian osteoclasts and in Dictyostelium, is the enzyme farnesyl diphosphate synthase (FDP synthase). The genetic evidence, obtained with Dictyostelium, derives from variant strains that over-express FDP synthase and that are relatively resistant to aBPs. We show that… (More)

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Cite this paper

@article{Sugden2005EngineeredGO, title={Engineered gene over-expression as a method of drug target identification.}, author={Christopher J Sugden and Janine R Roper and J. Patrick Williams}, journal={Biochemical and biophysical research communications}, year={2005}, volume={334 2}, pages={555-60} }