# Engineered gene circuits

@article{Hasty2002EngineeredGC,
title={Engineered gene circuits},
author={Jeff Hasty and David McMillen and James J. Collins},
journal={Nature},
year={2002},
volume={420},
pages={224-230}
}
A central focus of postgenomic research will be to understand how cellular phenomena arise from the connectivity of genes and proteins. This connectivity generates molecular network diagrams that resemble complex electrical circuits, and a systematic understanding will require the development of a mathematical framework for describing the circuitry. From an engineering perspective, the natural path towards such a framework is the construction and analysis of the underlying submodules that… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

#### Citations

##### Publications citing this paper.
Showing 1-10 of 292 extracted citations

## A Novel Mixed-Signal Integrated Circuit Model for DNA-Protein Regulatory Genetic Circuits and Genetic State Machines

IEEE Transactions on Circuits and Systems I: Regular Papers • 2008
View 5 Excerpts
Highly Influenced

## The Stochastic Evolutionary Game for a Population of Biological Networks Under Natural Selection

Evolutionary bioinformatics online • 2014
View 4 Excerpts
Highly Influenced

## Systems Biology as an Integrated Platform for Bioinformatics, Systems Synthetic Biology, and Systems Metabolic Engineering

Cells • 2013
View 5 Excerpts
Highly Influenced

## Design of Synthetic Genetic Oscillators Based on RSGA

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering • 2011
View 4 Excerpts
Highly Influenced

## On the Interplay between Entropy and Robustness of Gene Regulatory Networks

Entropy • 2010
View 4 Excerpts
Highly Influenced

## Robust H ∞ Feedback Control for Uncertain Stochastic Delayed Genetic Regulatory Networks with Additive and Multiplicative Noise

2009
View 16 Excerpts
Highly Influenced

## A Micro-sequenced CMOS Model for Cell Signaling Pathway using G-Protein and Phosphorylation Cascade

2008 15th International Conference on Mechatronics and Machine Vision in Practice • 2008
View 4 Excerpts
Highly Influenced

## A systematic molecular circuit design method for gene networks under biochemical time delays and molecular noises

BMC Systems Biology • 2008
View 6 Excerpts
Highly Influenced

## Robust $H_{\infty}$-Stabilization Design in Gene Networks Under Stochastic Molecular Noises: Fuzzy-Interpolation Approach

IEEE Transactions on Systems, Man, and Cybernetics, Part B (Cybernetics) • 2008
View 4 Excerpts
Highly Influenced

## Computational design of digital and memory biological devices

Systems and Synthetic Biology • 2007
View 4 Excerpts
Highly Influenced

#### References

##### Publications referenced by this paper.
Showing 1-10 of 60 references

## Reverse engineering gene networks: integrating genetic perturbations with dynamical modeling.

Proceedings of the National Academy of Sciences of the United States of America • 2003

## Attenuation of noise in ultrasensitive signaling cascades.

Biophysical journal • 2002

Nature • 2002

Science • 2002

## Mechanisms of noise-resistance in genetic oscillators.

Proceedings of the National Academy of Sciences of the United States of America • 2002

## Regulation of noise in the expression of a single gene

Nature Genetics • 2002

## Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability.

Current opinion in cell biology • 2002

## Stability puzzles in phage lambda.

Physical review. E, Statistical, nonlinear, and soft matter physics • 2002

## Synchronizing genetic relaxation oscillators by intercell signaling.

Proceedings of the National Academy of Sciences of the United States of America • 2002

## Synthetic gene network for entraining and amplifying cellular oscillations.

Physical review letters • 2002