Engineered fungal polyketide biosynthesis in Pichia pastoris: a potential excellent host for polyketide production

  title={Engineered fungal polyketide biosynthesis in Pichia pastoris: a potential excellent host for polyketide production},
  author={Limei Gao and Menghao Cai and Wei Shen and Siwei Xiao and Xiangshan Zhou and Yuanxing Zhang},
  booktitle={Microbial cell factories},
BACKGROUND Polyketides are one of the most important classes of secondary metabolites and usually make good drugs. Currently, heterologous production of fungal polyketides for developing a high potential industrial application system with high production capacity and pharmaceutical feasibility was still at its infancy. Pichia pastoris is a highly successful system for the high production of a variety of heterologous proteins. In this work, we aim to develop a P. pastoris based in vivo fungal… CONTINUE READING


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