Engineered culture models for studies of tumor-microenvironment interactions.

  title={Engineered culture models for studies of tumor-microenvironment interactions.},
  author={David W. Infanger and Maureen E Lynch and Claudia Fischbach},
  journal={Annual review of biomedical engineering},
Heterogeneous microenvironmental conditions play critical roles in cancer pathogenesis and therapy resistance and arise from changes in tissue dimensionality, cell-extracellular matrix (ECM) interactions, soluble factor signaling, oxygen as well as metabolic gradients, and exogeneous biomechanical cues. Traditional cell culture approaches are restricted in their ability to mimic this complexity with physiological relevance, offering only partial explanation as to why novel therapeutic compounds… CONTINUE READING

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