Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection.

@article{Saville2003EngineeredCO,
  title={Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection.},
  author={Stephen P. Saville and Anna L. Lazzell and Carlos Hern{\'a}ndez – Monteagudo and Jos{\'e} Luis L{\'o}pez-Ribot},
  journal={Eukaryotic cell},
  year={2003},
  volume={2 5},
  pages={1053-60}
}
It is widely assumed that the ability of Candida albicans to switch between different morphologies is required for pathogenesis. However, most virulence studies have used mutants that are permanently locked into either the yeast or filamentous forms which are avirulent but unsuitable for discerning the role of morphogenetic conversions at the various stages of the infectious process. We have constructed a strain in which this developmental transition can be externally modulated both in vitro… CONTINUE READING
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Morphogenetic signaling pathways in Candida albicans, p. 95–106

  • A.J.P. Brown
  • 2002

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