Engineered composite tissue as a bioartificial limb graft.

  title={Engineered composite tissue as a bioartificial limb graft.},
  author={Bernhard J Jank and Linjie Xiong and Philipp T Moser and Jacques Paul Guyette and Xi Ren and Curtis Lisante Cetrulo and David A. Leonard and Leopoldo Jose Fernandez and Shawn P. Fagan and Harald Ott},
The loss of an extremity is a disastrous injury with tremendous impact on a patient's life. Current mechanical prostheses are technically highly sophisticated, but only partially replace physiologic function and aesthetic appearance. As a biologic alternative, approximately 70 patients have undergone allogeneic hand transplantation to date worldwide. While outcomes are favorable, risks and side effects of transplantation and long-term immunosuppression pose a significant ethical dilemma. An… CONTINUE READING
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