Engineered bacterial outer membrane vesicles with enhanced functionality.

@article{Kim2008EngineeredBO,
  title={Engineered bacterial outer membrane vesicles with enhanced functionality.},
  author={J E Kim and Anne M. Doody and David J. Chen and Gina H Cremona and Michael L Shuler and David D Putnam and Matthew P DeLisa},
  journal={Journal of molecular biology},
  year={2008},
  volume={380 1},
  pages={51-66}
}
We have engineered bacterial outer membrane vesicles (OMVs) with dramatically enhanced functionality by fusing several heterologous proteins to the vesicle-associated toxin ClyA of Escherichia coli. Similar to native unfused ClyA, chimeric ClyA fusion proteins were found localized in bacterial OMVs and retained activity of the fusion partners, demonstrating for the first time that ClyA can be used to co-localize fully functional heterologous proteins directly in bacterial OMVs. For instance… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

The Therapeutic Benefit of Bacterial Membrane Vesicles

International journal of molecular sciences • 2017
View 4 Excerpts
Highly Influenced

- 1-decoration of Outer Membrane Vesicles with Multiple 1 Antigens Using an Autotransporter Approach 2 3

Maria H Daleke-Schermerhorna, Tristan Felixc, +19 authors Joen Luirinka
2014
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 68 references

Immunoliposomes for cancer therapy.

Current opinion in molecular therapeutics • 2006
View 1 Excerpt

Similar Papers

Loading similar papers…