Engineered anti-CD38 monoclonal antibodies for immunotherapy of multiple myeloma.

  title={Engineered anti-CD38 monoclonal antibodies for immunotherapy of multiple myeloma.},
  author={Jonathan H. Ellis and Karen A R Barber and Alison L. Tutt and Christine Hale and Alan P. Lewis and Martin J. Glennie and George T. Stevenson and J. S. Crowe},
  journal={Journal of immunology},
  volume={155 2},
Multiple myeloma is a malignancy of plasma cells for which there is no effective treatment. To develop an immunotherapeutic agent, we have raised a high affinity mAb (AT13/5) against CD38, one of the few well-characterized surface Ags present on myeloma cells. Since murine monoclonals have many disadvantages as human therapeutics, we prepared two engineered forms of the Ab: a CDR-grafted humanized IgG1 and a chimeric FabFc2 (mouse Fab cross-linked to two human gamma 1 Fc). To retain affinity in… CONTINUE READING


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