Engineered Zinc Finger Protein–Mediated VEGF-A Activation Restores Deficient VEGF-A in Sensory Neurons in Experimental Diabetes

@inproceedings{Pawson2010EngineeredZF,
  title={Engineered Zinc Finger Protein–Mediated VEGF-A Activation Restores Deficient VEGF-A in Sensory Neurons in Experimental Diabetes},
  author={Elizabeth J. Pawson and Beatriz Duran-Jimenez and Richard T Surosky and Heather E. Brooke and Sharon Kaye Spratt and David Richard Tomlinson and Natalie J Gardiner},
  booktitle={Diabetes},
  year={2010}
}
OBJECTIVE The objectives of the study were to evaluate retrograde axonal transport of vascular endothelial growth factor A (VEGF-A) protein to sensory neurons after intramuscular administration of an engineered zinc finger protein activator of endogenous VEGF-A (VZ+434) in an experimental model of diabetes, and to characterize the VEGF-A target neurons. RESEARCH DESIGN AND METHODS We compared the expression of VEGF-A in lumbar (L)4/5 dorsal root ganglia (DRG) of control rats and VZ+434… CONTINUE READING