Engineered GPCRs as tools to modulate signal transduction.

Abstract

Different families of G-protein-coupled receptors (GPCRs) have been engineered to provide exclusive control over the activation of these receptors and thus to understand better the consequences of their signaling in vitro and in vivo. These engineered receptors, named RASSLs (receptors activated solely by synthetic ligands) and DREADDs (designer receptors… (More)
DOI: 10.1152/physiol.00025.2008

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