Engineered E. coli that detect and respond to gut inflammation through nitric oxide sensing.

Abstract

Advances in synthetic biology now allow for the reprogramming of microorganisms to execute specific tasks. Here, we describe the development of an engineered strain of E. coli capable of sensing and responding to the presence of a mammalian inflammatory signal. The synthetic gene regulatory circuit is designed to permanently alter gene expression in… (More)
DOI: 10.1021/sb3000595

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