Corpus ID: 89770396

Engineered C-reactive protein with improved protective action against pneumococcal infection

@article{Ngwa2016EngineeredCP,
  title={Engineered C-reactive protein with improved protective action against pneumococcal infection},
  author={D. N. Ngwa and Toh B. Gang and Sanjay K. Singh and A. Agrawal},
  journal={Journal of Immunology},
  year={2016},
  volume={196}
}
The anti-pneumococcal function of native C-reactive protein (CRP) involves the binding of CRP to phosphocholine molecules present on Streptococcus pneumoniae and subsequent activation of the complement system. However, when pneumococci recruit complement inhibitory protein factor H on their surface, they escape the attack of complement. We have reported previously that CRP, in a non-native conformation, expresses the ability to bind immobilized factor H. Accordingly, we hypothesized that such… Expand
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