Engagement of the CD19 receptor on human B-lineage leukemia cells activates LCK tyrosine kinase and facilitates radiation-induced apoptosis.

@article{Waddick1993EngagementOT,
  title={Engagement of the CD19 receptor on human B-lineage leukemia cells activates LCK tyrosine kinase and facilitates radiation-induced apoptosis.},
  author={Kevin G. Waddick and H P Chae and Lisa Tuel-Ahlgren and L J Jarvis and Ilker Dibirdik and Damian E. Myers and Fatih M. Uckun},
  journal={Radiation research},
  year={1993},
  volume={136 3},
  pages={313-9}
}
As presently reported, both ionizing radiation and engagement of the CD19 receptor are capable of inducing apoptosis in B-lineage acute lymphoblastic leukemia (ALL) cells. In both instances, activation of tyrosine kinases appears to be a proximal and mandatory step, since it can be prevented by the tyrosine kinase inhibitor genistein. This common biochemical signaling pathway involves the rapid activation of the Src family tyrosine kinase LCK (p56lck), which is physically associated with the… CONTINUE READING