Engagement of endogenous ganglioside GM1a induces tyrosine phosphorylation involved in neuron-like differentiation of PC12 cells.

@article{Kimura2001EngagementOE,
  title={Engagement of endogenous ganglioside GM1a induces tyrosine phosphorylation involved in neuron-like differentiation of PC12 cells.},
  author={Masato Kimura and Kazuya I. P. J. Hidari and Toshio Suzuki and Daisei Miyamoto and Yoshihiro Suzuki},
  journal={Glycobiology},
  year={2001},
  volume={11 4},
  pages={
          335-43
        }
}
Using the cholera toxin B subunit (CTB) that specifically binds to ganglioside GM1a on the plasma membrane, we investigated intracellular signaling mediated by endogenous GM1a involved in neuronal differentiation of PC12 cells. The treatment with CTB induced morphological alternations of PC12 cells, such as augmentation of the cell body, neurite extension, and branched spikes of tips of neurites. The neurite extension induced with CTB was strongly suppressed by the pretreatment of tyrosine… CONTINUE READING
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