Engagement of NOD2 has a dual effect on proIL-1beta mRNA transcription and secretion of bioactive IL-1beta.

@article{Ferwerda2008EngagementON,
  title={Engagement of NOD2 has a dual effect on proIL-1beta mRNA transcription and secretion of bioactive IL-1beta.},
  author={Gerben Ferwerda and Matthijs Kramer and Dirk J de Jong and Alessandra Piccini and Leo A B Joosten and Isabel Devesaginer and Stephen E. Girardin and Gosse J Adema and Jos W M van der Meer and B. -J. Kullberg and Anna Rubartelli and Mihai G Netea},
  journal={European journal of immunology},
  year={2008},
  volume={38 1},
  pages={184-91}
}
Synthesis and release of pro-inflammatory cytokines, such as IL-1beta, play a crucial role in the intestinal inflammation that characterizes Crohn's disease. Mutations in the nucleotide oligomerization domain 2 (NOD2) gene are associated with an increased risk of Crohn's disease. Although it is known that NOD2 mediates cytokine responses to muramyl dipeptide (MDP), it is yet unclear whether NOD2 stimulation mediates only transcription of pro-IL-1beta mRNA, or whether NOD2 is also involved in… CONTINUE READING

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