Engagement of I-branching {beta}-1, 6-N-acetylglucosaminyltransferase 2 in breast cancer metastasis and TGF-{beta} signaling.

@article{Zhang2011EngagementOI,
  title={Engagement of I-branching \{beta\}-1, 6-N-acetylglucosaminyltransferase 2 in breast cancer metastasis and TGF-\{beta\} signaling.},
  author={Haijun Zhang and Fanyan Meng and Sherwin Wu and Bas Kreike and Seema Sethi and Wei Chen and F. Roy Miller and Guojun Wu},
  journal={Cancer research},
  year={2011},
  volume={71 14},
  pages={4846-56}
}
In this study, we have showed that GCNT2, a gene-encoding glucosaminyl (N-acetyl) transferase 2, I-branching enzyme, is overexpressed in highly metastatic breast cancer cell lines of human and mouse origin and basal-like breast tumor samples. GCNT2 expression is also significantly correlated to the metastatic phenotype in breast tumor samples. Functional studies showed that ectopic expression of GCNT2 enhances cell detachment, adhesion to endothelial cells, cell migration and invasion in vitro… CONTINUE READING
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