Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin.

@article{Coffey2009EngagementOC,
  title={Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin.},
  author={Greg P. Coffey and Ranjani Rajapaksa and Raymond A. Liu and Orr Sharpe and C L Kuo and Sharon Wald Krauss and Yael Sagi and R Eric Davis and Louis M. Staudt and Jeff P. Sharman and William H. Robinson and S. Y. Levy},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 17},
  pages={3137-44}
}
CD81 is a tetraspanin family member involved in diverse cellular interactions in the immune and nervous systems and in cell fusion events. However, the mechanism of action of CD81 and of other tetraspanins has not been defined. We reasoned that identifying signaling molecules downstream of CD81 would provide mechanistic clues. We engaged CD81 on the surface of B-lymphocytes and identified the induced tyrosine-phosphorylated proteins by mass spectrometry. This analysis showed that the most… CONTINUE READING

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Ezrin and moesin function together to promote T cell activation.

Journal of immunology • 2009
View 14 Excerpts
Highly Influenced

The tetraspanin web modulates immune-signalling complexes

Nature Reviews Immunology • 2005
View 4 Excerpts
Highly Influenced

ERM proteins and merlin: integrators at the cell cortex

Nature Reviews Molecular Cell Biology • 2002
View 4 Excerpts
Highly Influenced

virus infection of human hepatocytes

A. Bretscher, K. Edwards, R. G. Fehon
J Virol • 2002
View 6 Excerpts
Highly Influenced

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