Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease.

@article{Paust2004EngagementOB,
  title={Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease.},
  author={Silke Paust and Linrong Lu and Nami McCarty and Harvey Cantor},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 28},
  pages={10398-403}
}
Although there is considerable evidence that a subpopulation of regulatory CD4(+)CD25+ T cells can suppress the response of autoreactive T cells, the underlying molecular mechanism is not understood. We find that transmission of a suppressive signal by CD4CD25+ regulatory cells requires engagement of the B7 molecule expressed on target T cells. The response of T cells from B7-deficient mice is resistant to suppression in vitro, and these cells provoke a lethal wasting disease in lymphopenic… CONTINUE READING

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