Enfuvirtide resistance mutations: impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralization.

@article{Reeves2005EnfuvirtideRM,
  title={Enfuvirtide resistance mutations: impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralization.},
  author={Jacqueline D. Reeves and Fang-Hua Lee and John L Miamidian and Cassandra B. Jabara and Marisa M. Juntilla and Robert W. Doms},
  journal={Journal of virology},
  year={2005},
  volume={79 8},
  pages={
          4991-9
        }
}
Enfuvirtide (ENF/T-20/Fuzeon), the first human immunodeficiency virus (HIV) entry inhibitor to be licensed, targets a structural intermediate of the entry process. ENF binds the HR1 domain in gp41 after Env has bound CD4, preventing conformational changes needed for membrane fusion. Mutations in HR1 that confer ENF resistance can arise following ENF therapy. ENF resistance mutations were introduced into an R5- and X4-tropic Env to examine their impact on fusion, infection, and sensitivity to… CONTINUE READING

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