Enforced expression of tissue inhibitor of matrix metalloproteinase-3 affects functional capillary morphogenesis and inhibits tumor growth in a murine tumor model.

@article{Spurbeck2002EnforcedEO,
  title={Enforced expression of tissue inhibitor of matrix metalloproteinase-3 affects functional capillary morphogenesis and inhibits tumor growth in a murine tumor model.},
  author={William W. Spurbeck and Catherine Y. C. Ng and Ted S. Strom and Elio Fausto Vanin and Andrew M. Davidoff},
  journal={Blood},
  year={2002},
  volume={100 9},
  pages={3361-8}
}
Homeostasis of the extracellular matrix is a delicate balance between degradation and remodeling, the balance being maintained by the interaction of activated matrix metalloproteinases (MMPs) and specific tissue inhibitors of matrix metalloproteinases (TIMPs). Up-regulation of MMP activity, favoring proteolytic degradation of the basement membrane and extracellular matrix, has been linked to tumor growth and metastasis, as well as tumor-associated angiogenesis, whereas inhibition of MMP… CONTINUE READING

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