Enforced expression of Simian virus 40 large T-antigen leads to testicular germ cell tumors in zebrafish.

@article{Gill2010EnforcedEO,
  title={Enforced expression of Simian virus 40 large T-antigen leads to testicular germ cell tumors in zebrafish.},
  author={James A Gill and Linda Lowe and Joan Nguyen and Piu Paul Liu and Trevor B. Blake and Byrappa Venkatesh and Peter D Aplan},
  journal={Zebrafish},
  year={2010},
  volume={7 4},
  pages={333-41}
}
Testicular germ cell tumors (TGCTs) are the most common malignancy in young men. However, there are few in vivo animal models that have been developed to study this disease. We have used the pufferfish (fugu) lymphocyte-specific protein tyrosine kinase (flck) promoter, which has been shown to enforce high-level expression in the testes of transgenic mice… CONTINUE READING