Enforced expression of HOXB7 promotes hematopoietic stem cell proliferation and myeloid-restricted progenitor differentiation

@article{Car1999EnforcedEO,
  title={Enforced expression of HOXB7 promotes hematopoietic stem cell proliferation and myeloid-restricted progenitor differentiation},
  author={Alessandra Car{\`e} and Mauro Valtieri and Gianfranco Mattia and Ettore Meccia and Barbara Masella and Luisella Luchetti and Federica Felicetti and M. P. Colombo and Cesare Peschle},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={1993-2001}
}
Hematopoietic progenitor/stem cells (HPCs/HSCs) purified from human adult peripheral blood (PB) were triggered into cycling, retrovirally transduced with HOXB7 and then functionally assayed in vitro. HPCs were assayed in multi- and unilineage differentiation cultures in either liquid phase or semisolid medium, primitive HPCs in the high proliferative… CONTINUE READING