Enforced bcl-xL gene expression restored splenic B lymphocyte development in BAFF-R mutant mice.

@article{Amanna2003EnforcedBG,
  title={Enforced bcl-xL gene expression restored splenic B lymphocyte development in BAFF-R mutant mice.},
  author={Ian J. Amanna and Jennifer P. Dingwall and Colleen Hayes},
  journal={Journal of immunology},
  year={2003},
  volume={170 9},
  pages={4593-600}
}
The TNFR family member BAFF-R facilitates peripheral B cell development, although it is unclear whether it promotes survival of B cells, or also initiates a differentiation program. We show that disruption of the BAFF-R encoding gene Tnfrsf13c in strain A/WySnJ mice causes a progressive decline in peripheral B cell numbers, beginning at the transitional 1 developmental stage and continuing through the mature peripheral B cell stage. Bcl-x(L) overexpression in A/WySnJ B cells decreased the… CONTINUE READING
34 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…