Enflurane inhibits NMDA, AMPA, and kainate‐induced currents in Xenopus oocytes expressing mouse and human brain mRNA

@article{Un1993EnfluraneIN,
  title={Enflurane inhibits NMDA, AMPA, and kainate‐induced currents in Xenopus oocytes expressing mouse and human brain mRNA},
  author={L Un and Longtang L. Chen and R. Adron Harris},
  journal={The FASEB Journal},
  year={1993},
  volume={7},
  pages={479 - 485}
}
Effects of enflurane, an inhalational anesthetic, on NMDA, AMPA, and kainate‐gated currents were examined in Xenopus laevis oocytes expressing mouse or human brain mRNA. In oocytes expressing mouse mRNA, enflurane at an anesthetic concentration (1.8 mM) inhibited the NMDA‐, AMPA‐, and kainate‐induced currents by 29–40%, 30–33%, and 20–27%, respectively, suggesting that all three glutamate ionotropic receptors are susceptible to suppression by inhalational anesthetics. Furthermore, inhibition by… Expand
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