Enflurane and methoxyflurane: their interaction with hepatic microsomal stearate desaturase.

@article{Ivanetich1980EnfluraneAM,
  title={Enflurane and methoxyflurane: their interaction with hepatic microsomal stearate desaturase.},
  author={K. Ivanetich and V. Manca and G. Harrison and M. Berman},
  journal={Biochemical pharmacology},
  year={1980},
  volume={29 1},
  pages={
          27-34
        }
}
  • K. Ivanetich, V. Manca, +1 author M. Berman
  • Published 1980
  • Chemistry, Medicine
  • Biochemical pharmacology
  • Abstract The effects of the volatile anesthetic agents enflurane (CClFHCF 2 OCF 2 H) and methoxyflurane (CCl 2 HCF 2 OCH 3 ) on hepatic microsomal electron transfer components and stearate desaturase are reported. Both enflurane and methoxyflurane stimulated electron now from NADH and NADPH through hepatic microsomal cytochrome b 5 . The stimulation of electron flow from cytochrome b 5 by the anesthetic agents was not inhibited by metyrapone or CO, but was inhibited by 0.5 mM KCN. The effects… CONTINUE READING

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