Enflurane and Methoxyflurane Metabolism at Anesthetic and at Subanesthetic Concentrations

@article{White1979EnfluraneAM,
  title={Enflurane and Methoxyflurane Metabolism at Anesthetic and at Subanesthetic Concentrations},
  author={Alice E. White and Wendell C. Stevens and Edmond I. Eger and Richard I. Maze and Ben A. Hitt},
  journal={Anesthesia \& Analgesia},
  year={1979},
  volume={58},
  pages={221–224}
}
In an attempt to determine the importance of concentration of an anesthetic agent as a determinant of the extent of its biotransformation, we measured fluoride excretion in groups of Fischer 344 rats treated with one of several subanesthetic or an anesthetic concentration (1 MAC) of either enflurane or methoxyflurane. Anesthetic administrations (2.0% enflurane or 0.26% methoxyflurane) ranged from 0.15 hours (9 minutes) to 4.8 hours. Subanesthetic exposures, all of 48 hours duration, ranged in… 
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