Enflurane and Methoxyflurane Metabolism at Anesthetic and at Subanesthetic Concentrations

  title={Enflurane and Methoxyflurane Metabolism at Anesthetic and at Subanesthetic Concentrations},
  author={Alice E. White and Wendell C. Stevens and Edmond I. Eger and Richard I. Maze and Ben A. Hitt},
  journal={Anesthesia \& Analgesia},
In an attempt to determine the importance of concentration of an anesthetic agent as a determinant of the extent of its biotransformation, we measured fluoride excretion in groups of Fischer 344 rats treated with one of several subanesthetic or an anesthetic concentration (1 MAC) of either enflurane or methoxyflurane. Anesthetic administrations (2.0% enflurane or 0.26% methoxyflurane) ranged from 0.15 hours (9 minutes) to 4.8 hours. Subanesthetic exposures, all of 48 hours duration, ranged in… 
10 Citations

Tables from this paper

Metabolic Ability and Enflurane Defluorination in Surgical Patients

In the material as a whole, the enflurane dose was positively correlated with both post‐anaesthetic highest serum fluoride concentrations and the 24‐h fluoride excretion in urine, and there was a correlation between the 24-h post-anaesthetic urine pH as well as urine volume and fluoride excretions during that time.

The uptake and disposition of enflurane during and following anesthesia in obese and non-obese humans

The disposition of enflurane, a volatile halogenated anesthetic 9 was studied in obese and non-obese subjects and Hepatic biopsies from obese subjects demonstrated high levels of fatty infiltration which were not related to the increased en flurane biotransformation observed.

In vitro effects of fluoride and bromide on pseudocholinesterase and acetylcholinesterase activities

It is recommended that blood drawing for PCHE activity be delayed at least until 24 hr following enflurane or sevoflurane anaesthesia, and caution is recommended when succinylcholine and/or ester type local anaesthetics are used in the immediate postoperative period following en fluraneor sev ofluranes anaesthesia.

Hypoxia May Be More Important than Reductive Metabolism in Halothane‐Induced Hepatic Injury

It is suggested that hypoxia per se may be more important than halothane metabolism in causing liver damage; high concentrations given briefly produced more damage than lower concentrations given for long periods.

Methoxyflurane toxicity: historical determination and lessons for modern patient and occupational exposure.

There are a number of pathways whereby repeated exposure to methoxyflurane in lower doses may pose a risk, and the safety of recurrent patient or occupational healthcare-worker exposure has not been confirmed, and merits further investigation.

Plasma Fluoride and Bromide Concentrations during Occupational Exposure to Enflurane or Halothane

The plasma fluoride and bromide concentrations were studied in operating theatre personnel. When enflurane was used, the increase in plasma fluoride concentration could not be distinguished from

Plasma fluoride concentration and urinary fluoride excretion in obese and non-obese patients following enflurane anesthesia

  • Y. Tohyama
  • Medicine, Biology
    Journal of Anesthesia
  • 2010
It is suggested that obese patients metabolized more enflurane than non-obese patients during the postanesthetic period, and their excess fatty tissue may cause a greater and more prolonged elevation of blood enFLurane concentrations after anesthesia.

Enflurane in clinical practice.

  • A. Adams
  • Medicine
    British journal of anaesthesia
  • 1981

Studying toxicity of inhaled general anaesthetics.

  • M. Halsey
  • Medicine
    British journal of anaesthesia
  • 1981



A comparison of the renal effects and metabolism of enflurane and methoxyflurane in Fischer 344 rats.

Serum inorganic fluoride level peaked earlier and returned to control values sooner after en flurane than after methoxyflurane anesthesia, and enzyme induction with phenobarbital did not increase the defluorination of enflurain or exacerbate its nephrotoxicity.

A Method for Determining Minimum Alveolar Concentration of Anesthetic in the Rat

Minimum alveclir concentrations (MAC) for halothane and methoxyflurane were determined at two stimulus intensities in the rat as the mean of the lowest alveolar concentration preventing and the highest permitting movement in response to the two stimuli.

Comparative Toxicities of Halothane, Isoflurane, and Diethyl Ether at Subanesthetic Concentrations in Laboratory Animals

Effects of 35-day exposures to subanesthetic concentrations of halothane, isoflurane, and diethyl ether were measured in mice, rats, and guinea pigs which were in a phase of rapid body growth.

The minimum alveolar concentration of enflurane in man.

The minimum alveolar concentration (MAC) of enflurane in man was found to be 1.68 per cent, a value close to that which would have been predicted, based on its lipid solubility.

Anesthetic uptake and action

Find loads of the anesthetic uptake and action book catalogues in this site as the choice of you visiting this page. You can also join to the website book library that will show you numerous books

Serum fluoride analysis with the fluoride electrode.

Eger El 11: Anesthetic Uptake and Action

  • 1971