Energy substrates for neurons during neural activity: a critical review of the astrocyte-neuron lactate shuttle hypothesis.

@article{Chih2003EnergySF,
  title={Energy substrates for neurons during neural activity: a critical review of the astrocyte-neuron lactate shuttle hypothesis.},
  author={C P Chih and E. M. Nemoto e. Owman J. L. Reid K. A. Reimer W. C. Roberts},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2003},
  volume={23 11},
  pages={1263-81}
}
Glucose had long been thought to fuel oxidative metabolism in active neurons until the recently proposed astrocyte-neuron lactate shuttle hypothesis (ANLSH) challenged this view. According to the ANLSH, activity-induced uptake of glucose takes place predominantly in astrocytes, which metabolize glucose anaerobically. Lactate produced from anaerobic glycolysis in astrocytes is then released from astrocytes and provides the primary metabolic fuel for neurons. The conventional hypothesis asserts… CONTINUE READING
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