Energy substrates and the completion of spontaneous meiotic maturation.

  title={Energy substrates and the completion of spontaneous meiotic maturation.},
  author={Stephen M Downs and Eddy Hudson},
  volume={8 4},
This study was carried out to examine how different combinations of pyruvate and glucose affect spontaneous meiotic maturation of cumulus-cell-enclosed mouse oocytes (CEO) to metaphase II (MII). Most experiments used an open system in which oocytes were cultured in 1 ml medium in plastic tubes. Initial experiments examined the dose response effects of pyruvate or glucose alone in the presence or absence of 2 mM glutamine. When medium lacked both pyruvate and glucose, more than 91% of the… CONTINUE READING


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