Energy substrate availability as a determinant of neuronal resting potential, GABA signaling and spontaneous network activity in the neonatal cortex in vitro

@article{Holmgren2010EnergySA,
  title={Energy substrate availability as a determinant of neuronal resting potential, GABA signaling and spontaneous network activity in the neonatal cortex in vitro},
  author={Carl D. Holmgren and Marat Mukhtarov and Anton E Malkov and Irina Yu. Popova and Piotr Bregestovski and Yuri Zilberter},
  journal={Journal of Neurochemistry},
  year={2010},
  volume={112}
}
J. Neurochem. (2009) 112, 900–912. 
Reality of Inhibitory GABA in Neonatal Brain: Time to Rewrite the Textbooks?
  • M. Zilberter
  • Psychology, Medicine
  • The Journal of Neuroscience
  • 2016
The issue of GABA action in the developing brain has been debated for several years. The accepted axiom has been that, in neonatal brain, GABA exerts a mainly excitatory effect on the network,Expand
Ion homeostasis, energy substrates, and network activity in developing brain
TLDR
Accumulating recent observations challenge the view that the excitatory action of GABAergic system stimulates synaptogenesis and the development of neuronal networks. Expand
Ketone bodies in epilepsy
J. Neurochem. (2012) 121, 28–35.
Critical State of Energy Metabolism in Brain Slices: The Principal Role of Oxygen Delivery and Energy Substrates in Shaping Neuronal Activity
TLDR
It is demonstrated that energy metabolism determines the functional state of neuronal network, highlighting the need for the adequate metabolic support to be insured in the in vitro experiments. Expand
Questioning the depolarizing effects of GABA during early brain development.
TLDR
Results are summarized that support and challenge the traditional point of view, and indicate some strong and weak points of both positions. Expand
Spontaneous Network Events Driven by Depolarizing GABA Action in Neonatal Hippocampal Slices are Not Attributable to Deficient Mitochondrial Energy Metabolism
TLDR
The main conclusions of this work are that the inhibitory effect of l-lactate on GDPs is not mediated by mitochondrial energy metabolism, and that glucose at its standard 10 mm concentration is an adequate energy substrate for neonatal neurons in vitro. Expand
Neuronal activity in vitro and the in vivo reality: the role of energy homeostasis.
TLDR
This paper discusses the relationships between availability of energy substrates and neuronal excitability, and suggests that for in vitro studies, it is crucial to optimize the composition of the energy pool in the extracellular milieu. Expand
Glucose is an adequate energy substrate for the depolarizing action of GABA and glycine in the neonatal rat spinal cord in vitro.
TLDR
It is concluded that depolarizing IPSPs in immature MNs and the primary afferent depolarizations are not caused by inadequate energy supply, and glucose at its standard concentration appears to be an adequate ES for the neonatal spinal cord in vitro. Expand
Recent progress in GABAergic excitation from mature brain
  • L. Chung
  • Biology, Medicine
  • Archives of pharmacal research
  • 2012
TLDR
In neural circuit activity, presumed GABAergic excitation was observed in basolateral amygdala during the study of a neuropeptide, cholecystokinin, and it may be implicated in epilepsy or anxiety in the adult brain. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 92 REFERENCES
Pathophysiology of neuronal energy crisis in Alzheimer's disease.
A large body of evidence indicates that sporadic Alzheimer’s disease (AD) is a vascular disorder with neurodegenerative consequences and needs to be treated and managed as such. Epidemiologic studies
Excitatory actions of gaba during development: the nature of the nurture
  • Y. Ben-Ari
  • Biology, Medicine
  • Nature Reviews Neuroscience
  • 2002
TLDR
This work proposes that GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions, and provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation. Expand
Neuroenergetics and the kinetic design of excitatory synapses
TLDR
How the brain's energy supply limits the maximum rate at which the brain can compute is investigated, and how the molecular components of excitatory synapses have evolved properties that are matched to the information processing they perform. Expand
GABAergic control of CA3-driven network events in the developing hippocampus.
TLDR
In the neonatal rat hippocampus, spontaneously occurring network events known as "Giant Depolarizing Potentials" (GDPs) are seen in vitro at a stage when GABAergic transmission is depolarizing, and appear to be an immature form of hippocampal sharp waves. Expand
GABA action in immature neocortical neurons directly depends on the availability of ketone bodies
TLDR
By inducing a hyperpolarizing shift in Em and modulating GABA signaling mode, KBs can efficiently control the excitability of neonatal cortical neurons. Expand
Lactate as an oxidizable substrate for rat brain in vitro during the perinatal period.
Foetal brain slices showed a high capacity for lactate oxidation in vitro during late gestation. This capacity remained high during the very early postnatal period, suggesting that lactate may playExpand
Neuronal glucose but not lactate utilization is positively correlated with NMDA‐induced neurotransmission and fluctuations in cytosolic Ca2+ levels
TLDR
It is shown that utilization of glucose but not lactate correlates with NMDA‐induced neurotransmitter glutamate release in cultured cerebellar neurons from mice and a cascade of events for the preferential neuronal utilized of glucose during neurotransmission is suggested and discussed in relation to the current understanding of neuronal energy metabolism. Expand
Energetic basis of brain activity: implications for neuroimaging
TLDR
MRS and fMRI experiments show that the majority of cerebral activity, which is often disregarded in imaging experiments, is ongoing even when the brain appears to be doing nothing. Expand
Energy metabolism in mammalian brain during development
TLDR
This review attempts to link the plethora of information on the maturation of the central nervous system with the ontogeny of ATP metabolism, placing special emphasis on variations that occur during development in different brain regions and across the mammalian species. Expand
Tonically active GABAA receptors: modulating gain and maintaining the tone
TLDR
Tonic GABAA-receptor-mediated signalling occurs in different brain regions, shows cell-type-specific differences in magnitude and pharmacology, and changes during brain development, and provides a potentially important new window onto neuronal information processing and pathological states such as epilepsy. Expand
...
1
2
3
4
5
...