Energy substrate availability as a determinant of neuronal resting potential, GABA signaling and spontaneous network activity in the neonatal cortex in vitro

@article{Holmgren2010EnergySA,
  title={Energy substrate availability as a determinant of neuronal resting potential, GABA signaling and spontaneous network activity in the neonatal cortex in vitro},
  author={Carl D. Holmgren and Marat Mukhtarov and Anton Malkov and Irina Yu. Popova and Piotr Bregestovski and Yuri Zilberter},
  journal={Journal of Neurochemistry},
  year={2010},
  volume={112}
}
J. Neurochem. (2009) 112, 900–912. 

Reality of Inhibitory GABA in Neonatal Brain: Time to Rewrite the Textbooks?

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It is demonstrated that energy metabolism determines the functional state of neuronal network, highlighting the need for the adequate metabolic support to be insured in the in vitro experiments.

Questioning the depolarizing effects of GABA during early brain development.

Results are summarized that support and challenge the traditional point of view, and indicate some strong and weak points of both positions.

Spontaneous Network Events Driven by Depolarizing GABA Action in Neonatal Hippocampal Slices are Not Attributable to Deficient Mitochondrial Energy Metabolism

The main conclusions of this work are that the inhibitory effect of l-lactate on GDPs is not mediated by mitochondrial energy metabolism, and that glucose at its standard 10 mm concentration is an adequate energy substrate for neonatal neurons in vitro.

Glucose is an adequate energy substrate for the depolarizing action of GABA and glycine in the neonatal rat spinal cord in vitro.

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Recent progress in GABAergic excitation from mature brain

  • L. Chung
  • Biology, Psychology
    Archives of pharmacal research
  • 2012
In neural circuit activity, presumed GABAergic excitation was observed in basolateral amygdala during the study of a neuropeptide, cholecystokinin, and it may be implicated in epilepsy or anxiety in the adult brain.
...

References

SHOWING 1-10 OF 91 REFERENCES

Pathophysiology of neuronal energy crisis in Alzheimer's disease.

A large body of evidence indicates that sporadic Alzheimer’s disease (AD) is a vascular disorder with neurodegenerative consequences and needs to be treated and managed as such. Epidemiologic studies

Excitatory actions of gaba during development: the nature of the nurture

This work proposes that GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions, and provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation.

Neuroenergetics and the kinetic design of excitatory synapses

How the brain's energy supply limits the maximum rate at which the brain can compute is investigated, and how the molecular components of excitatory synapses have evolved properties that are matched to the information processing they perform.

GABAergic control of CA3-driven network events in the developing hippocampus.

In the neonatal rat hippocampus, spontaneously occurring network events known as "Giant Depolarizing Potentials" (GDPs) are seen in vitro at a stage when GABAergic transmission is depolarizing, and appear to be an immature form of hippocampal sharp waves.

GABA action in immature neocortical neurons directly depends on the availability of ketone bodies

By inducing a hyperpolarizing shift in Em and modulating GABA signaling mode, KBs can efficiently control the excitability of neonatal cortical neurons.

Lactate as an oxidizable substrate for rat brain in vitro during the perinatal period.

Foetal brain slices showed a high capacity for lactate oxidation in vitro during late gestation. This capacity remained high during the very early postnatal period, suggesting that lactate may play

Neuronal glucose but not lactate utilization is positively correlated with NMDA‐induced neurotransmission and fluctuations in cytosolic Ca2+ levels

It is shown that utilization of glucose but not lactate correlates with NMDA‐induced neurotransmitter glutamate release in cultured cerebellar neurons from mice and a cascade of events for the preferential neuronal utilized of glucose during neurotransmission is suggested and discussed in relation to the current understanding of neuronal energy metabolism.

Energy metabolism in mammalian brain during development

Tonically active GABAA receptors: modulating gain and maintaining the tone

...