Energy status determines the distinct biochemical and physiological behavior of interfibrillar and sub-sarcolemmal mitochondria.

@article{Kurian2012EnergySD,
  title={Energy status determines the distinct biochemical and physiological behavior of interfibrillar and sub-sarcolemmal mitochondria.},
  author={Gino A Kurian and Eduard Berenshtein and Or Kakhlon and Mordechai Chevion},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={428 3},
  pages={
          376-82
        }
}
Reports about the effect of ischemia and reperfusion on specific activities of the respiratory chain are often discrepant. One of the factors that govern this discrepancy is that typical mechanical procedures for mitochondrial isolation yield largely sub-sarcolemmal mitochondria (SSM), while the interfibrillar mitochondria (IFM), which provide most of the energy for the contractile apparatus, are under-represented. Here we investigated the impact of myocardial ischemia and reperfusion on SSM… CONTINUE READING
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